Monday, June 16, 2008

New Adult Stem Cell Research Provides Hope in Fight Against Parkinson's and Other Diseases of Old Age

Bio-engineers at California University have presented evidence that "old" stem cells are still able to perform regenerative functions if they receive appropriate chemical signals. This builds on earlier findings that when adult stem cells derived from "old" tissue are placed in an environment of young blood, the stem cells behave as if they are young again as well.

Because the findings bear on adult stem cells in existing tissue, this approach to rejuvenating degenerating muscle, bypasses medico-ethical complications associated with tissues from embryonic stem cells.

"We are one step closer to having a point of intervention where we can rejuvenate the body's own stem cells so we don't have to suffer from some of the debilitating diseases associated with ageing," said the study's co-author, Morgan Carlson.

The findings of the study were published Sunday in an advanced online issue of the journal Nature.

Meanwhile, in Australia, scientists have discovered that stem cells found in the back of a patient's nose can produce dopamine, the chemical which is missing in people with Parkinson's disease, the affliction endured by such people as Muhammad Ali and Michael J. Fox.

Parkinson's disease occurs when the brain cells that produce the chemical dopamine stop working. Without dopamine, nerve cells cannot function, leading to muscle problems.

Researchers from Griffith University and the University of Queensland harvested adult stem cells from the noses of Parkinson's disease patients. They found that once the nose cells were cultured and infused into animals with Parkinson's disease, the cells began to produce dopamine.

Professor Peter Silburn from the University of Queensland said it was an important breakthrough, as the cells could be easily harvested from patients. He said the next step was to test the cells in primates, then move to human trials in the next three years.